Paracetamol vs Ibuprofen for PDA Closure in Preterm Infants.
Status:
Suspended
Trial end date:
2019-10-31
Target enrollment:
Participant gender:
Summary
Current pharmacological options to treat an hemodynamically significant PDA (HsPDA) in
preterm infants are limited to non-selective cyclo-oxygenase (COX) inhibitors, indomethacin
or ibuprofen. Recently paracetamol exposure has been reported to successful closure of PDA.
Aim of this randomized double-blind controlled study is to compare the efficacy and the
safety of standard PDA treatment ibuprofen versus paracetamol-experimental treatment . We
hypothesize that paracetamol is more effective than ibuprofen in closing PDA, perhaps
ameliorating the safety profile of the pharmacological treatment.