Paracetamol Versus Ibuprofen for PDA Closure

• Status: Unknown status
• Trial end date: 2018-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Comparison between the safety and efficacy of oral paracetamol and oral ibuprofen in treatment of Patent Ductus Arteriosus (PDA) in premature infants

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Acetaminophen; Ibuprofen

Criteria

Inclusion Criteria:

1. Gestational age ≤ 35 weeks

2. Aged 2-7 days with color Doppler echocardiographic evidence of PDA

3. Urine output more than 1 ml/kg/hr

4. Creatinine concentration level less than 1.8 mg/dl

Exclusion Criteria:

Neonates who have one or more of the following criteria were excluded from the study:

1. Congenital heart diseases of any type including

• Pulmonary stenosis

• Anomalus in pulmonary venous drainage

• Ventricular septal defect

2. Major congenital anomalies as hydrops fetalis

3. Low platelets count (less than 60, 000/mm3)