Despite its use for decades all over the world, the exact mechanism of action of paracetamol
is not fully understood and essentially involves a combination of hypotheses. It is known to
have an effect via the central nervous system, and of the many mechanisms proposed, one
hypothesis is that it may have indirectly activate CB1 (cannabinoid) receptors, through its
novel metabolite AM404.
This study aims to elucidate cerebrospinal levels of paracetamol and to measure the
concentration of its metabolites, including AM404 in CSF. This may, in turn, give us useful
information on the mechanism of action of paracetamol.