Overview

Panitumumab With or Without Trametinib in Treating Patients With Stage IV Colorectal Cancer

Status:
Recruiting
Trial end date:
2021-12-30
Target enrollment:
Participant gender:
Summary
This phase II clinical trial studies how well panitumumab with or without trametinib works in treating patients with stage IV colorectal cancer. Immunotherapy with monoclonal antibodies, such as panitumumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving panitumumab with or without trametinib may work better in treating patients with stage IV colorectal cancer.
Phase:
Phase 2
Details
Lead Sponsor:
M.D. Anderson Cancer Center
Collaborators:
Amgen
National Cancer Institute (NCI)
Novartis
Treatments:
Antibodies
Antibodies, Monoclonal
Antineoplastic Agents, Immunological
Cetuximab
Immunoglobulins
Panitumumab
Trametinib