The reason for increased cardiac mortality in panic disorder has not been precisely
identified, but possibly is due to chronic activation of the cardiac stimulant (sympathetic)
nerves, which may predispose the individual with panic disorder to disorders of cardiac
rhythm and coronary artery spasm. The uniqueness of this study lies in its comprehensive
evaluation of a psychobiological approach to the treatment of panic disorder using change in
biological, behavioural and psychological variables as criteria for efficacy. 50 patients
aged between 18 and 60 years will be recruited; both males and females. They will be treated
with either cognitive behavioural therapy (CBT) or SSRI (selective serotonin re-uptake
inhibitor) antidepressants or a combination of both.
This project will firstly compare individuals with panic disorder who demonstrate abnormal
brain transmitter (noradrenaline, serotonin) with those who demonstrate normal activity of
these neurotransmitters, on interoceptive accuracy for changes in sympathetic nervous system
arousal. It is predicted that individuals who demonstrate abnormal activity of these
neurotransmitters will also demonstrate enhanced interoceptive ability to detect changes in
arousal levels. Secondly, this project will evaluate the effects of a psychobiological
treatment approach to panic disorder involving a combination of CBT and SSRI. This approach
will be compared to the effects of both these interventions alone on a comprehensive array of
measures related to panic disorder. It is predicted that the combined approach will be the
most effective intervention on behavioural, psychological and biological variables, and
cardiac risk. We will also be able to assess whether changes in panic disorder severity are
associated with changes in interoceptive accuracy.
Phase:
N/A
Details
Lead Sponsor:
Baker Heart Research Institute
Collaborator:
National Health and Medical Research Council, Australia