Pain Treatment After Total Knee Replacement - Continuous Epidural Versus Intravenous Patient Controlled Analgesia With Morphine

• Status: Terminated
• Trial end date: 2007-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The study purpose is to compare the effectiveness of different methods for post-operative pain treatment after total knee replacement.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rambam Health Care Campus
• Treatments: Bupivacaine; Fentanyl; Morphine

Criteria

Inclusion Criteria:

• Informed consent

• Age: 55 to 85 years

• Osteoarthritis

• Primary unilateral total knee replacement

• American Society of Anesthesiologists (ASA) I-III

• Successful spinal epidural anesthesia for surgery

Exclusion Criteria:

• Any cause for knee replacement other than osteoarthritis

• Total knee revision (re-do)

• Any contraindication for regional anesthesia

• Abnormal coagulation studies

• Thrombocytopenia less than 100,000/cc

• Chronic renal failure (creatinine [cr] < 1.8)

• Neurological disease involving lower extremities

• Major surgery during the last 2 weeks pre-operatively

• Current or past drug or alcohol abuse

• Allergy to study medications

• Post-operative bleeding over 2000 cc/24 hours

• Postdural puncture headache after anesthesia performance