Pain Prevention and Treatment Through the Enhancement of the Anti-nociceptive Component of Pain Modulation Profiles

• Status: Completed
• Trial end date: 2015-01-01
• Target enrollment: 0
• Participant gender: All

Summary

To utilize the plasticity of the central pain pathways in order to (i) shift individuals with a pro-nociceptive pain modulation profile towards an anti-nociceptive one, and (ii) assess its relevance in minimizing pain-derived morbidity.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Rambam Health Care Campus
• Treatments: Duloxetine Hydrochloride; Pregabalin

Criteria

Inclusion Criteria:

• Otherwise healthy, age 18-75.

Exclusion Criteria:

• Regular use of analgesia for any purpose, including SNRIs, gabapentins, COX inhibitors.

• Presence of diagnosed chronic pain disorders, psychiatric disorders, cognitive and /or neurological deficit.

• Inability to give informed consent, communicate and understand the purpose and instructions of this study.

• Pregnant or nursing women.