Chorionic villous sampling is a frequent procedure used for antenatal genetic testing. This
procedure is associated with anxiety and fear of pain that can be expected during the
procedure, often prejudicing patients against this definitive antenatal testing. It is
important to determine if different approaches to pain and anxiety reduction are effective.
Currently there is no randomized study to evaluate the efficacy of analgesia for pain
reduction during chorionic villous sampling. Multiple studies have been published suggesting
that analgesia during the similar procedure of amniocentesis does not significantly reduce
pain scores.