Pain Management in Osteoarthritis Using the Centrally Acting Analgesics Duloxetine and Pregabalin

• Status: Completed
• Trial end date: 2016-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Osteoarthritis is the most common form of arthritis worldwide. Specifically, osteoarthritis of the hands affects millions of people and is a major cause of hand disability and pain. Despite this, there are currently no treatments that delay or halt the development of osteoarthritis. Pain is one of the major symptoms of osteoarthritis and pain management is an important factor to consider in the treatment of this condition. Treatments for pain in osteoarthritis consists of local injections, anti-inflammatory gels or painkillers such as paracetamol. However, most people with osteoarthritis still have pain despite these treatments.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: St George's, University of London
• Collaborator: Rosetrees Trust
• Treatments: Analgesics; Duloxetine Hydrochloride; Pregabalin

Criteria

Inclusion Criteria:

• Participants fulfilling the American College of Rheumatology (ACR) criteria for the diagnosis of hand osteoarthritis

• Participants with hand osteoarthritis presenting to rheumatology outpatient clinics and primary care.

• Participants will be right or left handed

• Male or female

• Age between 40 and 75

• Participants will be on usual care for hand osteoarthritis including paracetamol and/or non-steroidal anti-inflammatory drugs

Exclusion Criteria:

• Participants with other rheumatological diagnoses e.g. rheumatoid arthritis

• Current or planned pregnancy

• Contraindications to duloxetine or pregabalin

• History of depression

• Recent surgery

• Previous use of duloxetine and/or pregabalin