Paclitaxel and Irinotecan in Advanced Gastric Cancer
Status:
Completed
Trial end date:
2011-08-01
Target enrollment:
Participant gender:
Summary
- Usually the combination of fluoropyrimidine with platinum is used as a first line
chemotherapy (for example, 5-FU+cisplatin, capecitabine+cisplatin, S-1+ cisplatin,
5-FU+oxaliplatin) in advanced gastric cancer.
- After failure with this combination, taxane-based regimen or irinotecan-based regimen is
usually used. But, as a second-line regimen, the combination of topoisomerase inhibitor
with taxane has not been fully evaluated until now.
- So we designed this phase I/II study to evaluate the efficacy and toxicity of
second-line chemotherapy with paclitaxel and irinotecan in fluoropyrimidine and
platinum-pretreated advanced gastric cancer.