Paclitaxel and CBT-1(Registered Trademark) to Treat Solid Tumors
Status:
Completed
Trial end date:
2009-06-01
Target enrollment:
Participant gender:
Summary
Background:
- Some cancer cells have a large amount of a protein called P-glycoprotein, which can pump
certain chemotherapy drugs out of their cells. This pump may be part of the reason why
it is difficult to shrink some cancers with chemotherapy.
- In laboratory experiments, the drug CBT-1(Registered Trademark) blocked the
P-glycoprotein pump, resulting in accumulation of higher amounts of chemotherapy inside
the cancer cells, making the chemotherapy more effective.
- Paclitaxel is a cancer drug that has caused tumors to shrink in many types of cancers,
including lung, ovarian, breast, renal, cervical and others.
Objectives:
- To determine whether CBT-1(Registered Trademark) can block the P-glycoprotein pump on
cancer cells and whether it inhibits the action of the pump found in normal blood cells
and liver tissue.
- To evaluate the effectiveness of combination therapy using CBT-1(Registered Trademark)
and paclitaxel in treating solid tumors and to determine whether the two drugs together
are more effective than paclitaxel alone.
Eligibility:
-Patients over 18 years of age who have a solid tumor that cannot be treated successfully
with standard treatments.
Design:
-Patients receive CBT-1(Registered Trademark) and paclitaxel in 21-day cycles. Treatment
continues for two cycles after all the cancer is gone, or until it is decided to surgically
remove some or all of the remaining cancer, or until the cancer has grown to the point where
it defined as progressive disease.
For each cycle, patients take CBT-1(Registered Trademark) by mouth in three divided doses
daily for 7 days. On day 6, paclitaxel is given through a vein over 3 hours.
Blood tests are done before starting CBT-1(Registered Trademark) and repeated periodically
throughout treatment.
Imaging studies computed tomography or magnetic resonance imaging (CT or MRI) are done every
two cycles. In addition, for the first cycle only, patients undergo imaging of tumors and
normal tissue with a 99mTc-sestamibi radionuclide scan before and after administration of
CBT-1(Registered Trademark). This scan helps show how well the P-glycoprotein pump is being
blocked by the treatment.