Paclitaxel and Bortezomib in Treating Patients With Metastatic or Unresectable Malignant Solid Tumors

• Status: Completed
• Trial end date: 2009-02-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Bortezomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving paclitaxel together with bortezomib may kill more tumor cells.

PURPOSE: This phase I trial is studying the side effects and best dose of paclitaxel and bortezomib in treating patients with metastatic or unresectable malignant solid tumors.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Medicine and Dentistry of New Jersey
• Collaborator: National Cancer Institute (NCI)
• Treatments: Albumin-Bound Paclitaxel; Bortezomib; Paclitaxel

Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed malignant solid tumor that involves an activated Ras/Raf/MAPK pathway, including the following:

• Breast cancer

• Prostate cancer

• Colon cancer

• Pancreatic cancer

• Ovarian cancer

• Non-small cell lung cancer

• Melanoma

• Papillary thyroid cancer

• Metastatic or unresectable disease

• Standard curative or palliative measures do not exist or are no longer effective

• No newly diagnosed, untreated, or uncontrolled brain metastases

PATIENT CHARACTERISTICS:

• ECOG performance status 0-2

• ANC ≥ 1,500/μL

• WBC ≥ 3,500/μL

• Platelet count ≥ 100,000/μL

• Total bilirubin ≤ 1.5 times upper limit of normal (ULN)

• AST/ALT ≤ 2.5 times ULN (≤ 5 times ULN for tumor involvement of the liver)

• Creatinine ≤ 2 times ULN

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception

• No neuropathy ≥ grade 1 with pain within the past 14 days

• No active infections

• No myocardial infarction within the past 6 months

• No NYHA class III or IV heart failure

• No uncontrolled angina

• No severe uncontrolled ventricular arrhythmias

• No evidence of acute ischemia or active conduction system abnormalities by ECG

• Any ECG abnormality at screening must be documented by the investigator as not medically relevant

• No hypersensitivity to bortezomib, boron, or mannitol

• No serious medical or psychiatric illness likely to interfere with study participation

PRIOR CONCURRENT THERAPY:

• Prior paclitaxel or bortezomib allowed

• At least 4 weeks since prior chemotherapy and/or radiotherapy

• More than 14 days since other prior investigational drugs

• No other concurrent investigational agents

• No other concurrent anticancer agents, including chemotherapy and biologic agents

• No concurrent recombinant interleukin-11 (Neumega®)