PROSPECTIVE ANALYSIS BETWEEN AMIODARONE Versus LIDOCAINE IN SVT

• Status: Recruiting
• Trial end date: 2022-08-02
• Target enrollment: 0
• Participant gender: All

Summary

Introduction: Recent studies have suggested that other medications may be superior to amiodarone in controlling ventricular arrhythmias. However, a prospective and randomized comparison with lidocaine has not yet been described.

Objective: This study aims to evaluate the effectiveness and safety of the use of amiodarone versus lidocaine in patients with stable ventricular tachycardias.

Methodology: For this, a unicentric, randomized and prospective study will be carried out, in which the two drugs will be administered in a comparative manner. Hospital data (test results, medical outcomes, arrhythmia reversal, complications) of patients will be analyzed for safety and effectiveness.

Expected results: The use of lidocaine is not inferior to amiodarone in the tolerability and reversion of stable ventricular tachycardias.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Sao Paulo General Hospital
• Treatments: Amiodarone; Anti-Arrhythmia Agents; Lidocaine

Criteria

Inclusion Criteria:

• Adult men and women> 18 years old

• Presence of sustained ventricular tachycardia with HR> 120 bpm

• Systolic blood pressure> 90 mmHg

• No signs of poor peripheral perfusion

• Absence of dyspnea

• Absence of severe angina

• Signed consent form

Exclusion Criteria:

• Pregnancy

• Hemodynamic instability

• Body mass index greater than 40 kg / m2

• Use of intravenous amiodarone or lidocaine in the last 24 hours

• Acute coronary syndrome

• Presence of tachycardia with irregular or supraventricular RR

• Contraindications to study drugs