PPG Project 3 - PET/MRI of the Brain-hematopoiesis-atherosclerosis Axis in PTSD Patients
Status:
Recruiting
Trial end date:
2022-02-28
Target enrollment:
Participant gender:
Summary
Project 3 of the PPG grant "Stress and Atherosclerotic Plaque Macrophages A Systems Biology
Approach," funded by the NHLBI, examines the relationship between psychosocial stress and
atherosclerotic inflammation, cell proliferation and burden using novel PET/MRI. Individuals
with post-traumatic stress disorder, trauma controls and healthy controls will be recruited
into a two-center clinical study. The study team will use functional MRI to examine the
relationship between activation of fear circuits in the brain and relate these data to
hematopoietic system activation, and vascular inflammation measured by FDG-PET, and
atherosclerotic burden measured by MRI.
Phase:
Early Phase 1
Details
Lead Sponsor:
Zahi Fayad
Collaborators:
Massachusetts General Hospital National Heart, Lung, and Blood Institute (NHLBI) National Institutes of Health (NIH)