PORH and Response to Cold in Raynaud's Phenomenon.

• Status: Unknown status
• Trial end date: 2017-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The main objective of the study is to determine if implication of epoxy-eicosatriénoïc acids (EETs) and NO during cutaneous post-occlusive hyperemia differs between patients with Raynaud phenomena and healthy volunteers, by studying hyperaemic postocclusive response after microinjection of fluconazole and L-NMMA at the dorsal side of the fingers.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital, Grenoble
• Treatments: Fluconazole

Criteria

Inclusion Criteria:

• Neither raynaud's phenomenon or chronic disease for healthy volunteers

• Raynaud's phenomenon without connective tissue disease for patients in the group "Raynaud"

Exclusion Criteria:

• History of axillary dissection , trauma or surgery

• History of thromboembolic disease or thrombophilia

• Minor or law-protected major

• Exclusion period in another study

• No affiliation to medicare

• Pregnant, parturient or breasting woman

• Concomitant serious disease: progressive cancer, liver failure, history of myocardial infarction less than 5 years, angor

• Smoking in the 6 last months

• Person deprived of liberty by a legal or administrative decision, person under legal protection

• Maximal annual indemnification reached.