Overview POISE Trial: Perioperative Ischemic Evaluation Study Status: Terminated Trial end date: 2007-08-01 Target enrollment: Participant gender: Summary This trial will evaluate the ability of metoprolol (a beta-blocker drug) to prevent heart attacks and deaths around the time of surgery. Phase: Phase 3 Details Lead Sponsor: Hamilton Health Sciences CorporationCollaborators: AstraZenecaBritish Heart FoundationCanadian Institutes of Health Research (CIHR)National Health and Medical Research Council, AustraliaTreatments: Metoprolol