PLAsticity, Security and Tolerance to Intermittent Hypoxic Conditioning Following Stroke
Status:
Not yet recruiting
Trial end date:
2024-12-31
Target enrollment:
Participant gender:
Summary
By inducing endogenous neuroprotection, hypoxic post-conditioning following stroke may
represent a harmless and efficient non-pharmacological innovative neuro-therapeutic modality
aiming at inducing neuroplasticity and brain repair, as supported by many preclinical
studies.
The investigators thus hypothesize that hypoxic post-conditioning represents a safe
therapeutic strategy post-stroke. The investigators further hypothesize that hypoxic
conditioning could enhance neuroplasticity and function in combination with conventional
rehabilitative care.
The primary study endpoint will be safety. Safety will be assessed through the clinical
review of the adverse events over the duration of the study, every 48 hours by a trained
evaluator, blinded for the therapeutic intervention.
The investigators will further investigate the potential functional benefits of such a
therapeutic approach on motor function, gait, balance, and cognition. The neurophysiological
substrates of hypoxic conditioning-triggered neuroplasticity at a subacute delay post-stroke
will also be investigated, based on biological and imagery markers.