PK Study of Tacrolimus and Cyclosporine When Co-Administered With Adefovir Dipivoxil in Post-Liver Transplant Patients

• Status: Completed
• Trial end date: 2005-05-01
• Target enrollment: 0
• Participant gender: All

Summary

Open-label pharmacokinetic drug interaction study.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Gilead Sciences
• Treatments: Adefovir; Adefovir dipivoxil; Cyclosporine; Cyclosporins; Tacrolimus

Criteria

Inclusion Criteria:

• 18-65 years of age

• Greater than or equal to 6 months post-liver transplantation

• Must be on a documented stable total daily dose of tacrolimus or cyclosporine for three months.

• Must have calculated creatinine clearance greater than or equal 50 mL/min (Cockcroft-Gault method).