PK/PD of Vaping THC-containing Liquids vs. Smoked Cannabis
Status:
Not yet recruiting
Trial end date:
2026-06-15
Target enrollment:
Participant gender:
Summary
We will conduct a randomized, within-subjects clinical study to compare short-term
pharmacokinetic (PK) and pharmacodynamic (PD) effects of Δ9-tetrahydrocannabinol (THC) vaping
liquids vs. smoked cannabis containing 6 equivalent standard THC units (5 mg THC=1 Standard
THC Unit (STU)) in healthy community members who are current users of both products. While
smoking cannabis remains the most common mode of THC use among adults and youth, alternative
modes of delivery, such as Electronic Vaping Products (EVPs), are becoming increasingly
popular for the delivery of cannabinoids. Declining cannabis risk perceptions, increasing
normalization of cannabis, greater legal access and availability to cannabis, ease of
administration, and ability to conceal vaped THC use have likely contributed to increasing
prevalence of use throughout the population across all age groups. Comparing vaping THC
containing liquids with smoking cannabis can serve as an important benchmark for evaluating
the delivery and effects of THC vaping products and, their relative safety