PK Intravenous Lidocaine Infusion

• Status: Terminated
• Trial end date: 2015-09-01
• Target enrollment: 0
• Participant gender: All

Summary

To determine safe concentration level of lidocaine infusion in children.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Children's Hospital Medical Center, Cincinnati
• Treatments: Lidocaine

Criteria

Inclusion Criteria:

• male or female children 3-15 years of age

• ASA physical status 1-3

• scheduled for colorectal surgery with abdominal incision

Exclusion Criteria:

• ASA physical status > 3

• postoperative intubation planned ahead of surgery

• history of chronic use of opioid (use longer than 3 months)

• history of hepatic, renal, or cardiac failure

• history of significant liver disease including liver failure, acute or chronic hepatitis, hepatomegaly, portal hypertension and elevated liver enzymes

• history of organ transplant

• BMI > 30

• history of cardiac arrhythmia

• history of long QT syndrome

• history of allergic reaction to lidocaine or similar agents

• history of seizure disorder

• patient without PICC or other central access with contraindication to inhalation induction

• family history or known patient susceptibility to malignant hyperthermia