PErsonalized Addition of Recombinant LH in Ovarian Stimulation
Status:
Recruiting
Trial end date:
2024-11-01
Target enrollment:
Participant gender:
Summary
Different ovarian stimulation regimens have shown to modify late follicular phase hormonal
profiles. Besides, recent studies confirm that progesterone levels and their variation in the
last day of oocyte maturation are affected by the dose of gonadotropins administered and by
other factors. Progesterone elevation in late follicular phase of in vitro
fertilization/intracytoplasmatic sperm injection (IVF/ICSI) cycles under ovarian stimulation
compromises implantation rates due to a negative effect on the endometrium. However, there is
still conflict in the literature questioning whether progesterone levels alone on the
triggering day is a sufficient indicator as progesterone does not give the full picture of
the ovarian functions, number of follicles as well as estrogen production that facilitate
endometrial growth, thus some studies suggest that especially in aged and poor responders
Progesterone/Estrogen (P4/E2) ratio has a better reflection (Progesterone (ng/mL)
×1,000/estradiol(pg/mL)) on the ovarian function.
The scope of the current pilot study is to compare serum progesterone levels as well as P4/E2
ratio on the day of ovulation triggering of women belonging to POSEIDON category group 2 who
undergo a new ovarian stimulation with a dose of rhFSH 300 IU or 300 IU rhFSH plus 150 IU
recombinant human luteinizing hormone (rhLH) in a gonadotropin-releasing hormone (GnRH)
antagonist protocol.