PET-Study: Effects of Single Doses of Stalevo and Levodopa/Carbidopa on Striatal 11C-Raclopride Binding
Status:
Terminated
Trial end date:
2008-05-01
Target enrollment:
Participant gender:
Summary
This is an open, randomised, active-controlled, 2-period crossover study comparing the effect
of single doses of Stalevo 200 and Sinemet on striatal (putamenal and caudate) 11C-raclopride
BP in PD patients with wearing-off symptoms. The study consists of 4 visits: a screening
visit (visit 1), 2 treatment periods (period 1=visit 2, period 2=visit 3) separated by a
minimum wash-out period of at least 3 days, and an end-of-study visit (visit 4). Subjects
will be randomly allocated to start the period 1 with a single dose of Stalevo 200 or
Sinemet. After the wash-out the study drug on period 2 will be administered according to a
crossover design.
Phase:
Phase 2
Details
Lead Sponsor:
Orion Corporation, Orion Pharma
Treatments:
Carbidopa Carbidopa, levodopa drug combination Entacapone Levodopa Raclopride