Several studies have implicated involvement of sigma-1 receptors (SR1s) in the generation of
chronic pain, while others are investigating anti SR1 drugs for treatment of chronic pain.
Using [18F]-FTC-146 and positron emission tomography/magnetic resonance imaging (PET/MRI),
the investigators hope to identify the source of pain generation in patients with chronic
pain. The purpose of this study is to compare the uptake of [18F]FTC-146 in healthy
volunteers to that of individuals suffering from chronic pain.