PET Imaging of the Dopaminergic and Serotonergic Systems in Treated HIV Positive Subjects
Status:
Recruiting
Trial end date:
2022-03-01
Target enrollment:
Participant gender:
Summary
Background:
Human immunodeficiency virus (HIV) infection is a serious disease with no cure. Some people
with HIV have depression and other mood problems. They can have problems with thinking and
memory. Researchers think 2 chemicals in the brain may cause those problems. The chemicals
are serotonin and dopamine. The researchers want to take images to learn more about those
chemicals in HIV patients.
Objective:
To learn how HIV affects serotonin and dopamine in the brain.
Eligibility:
Adults ages 18-70 with HIV who have been on antiretroviral treatment for at least 1 year
Healthy adults ages 18-70
All participants must be already enrolled in protocol 13-N-0149.
Design:
- Participants will be screened with a urine drug test. The results could be shared with
insurance companies.
- Participants who could be pregnant will have a pregnancy test.
- Participants may have a physical exam and blood tests.
- Participants will have 1 or 2 positron emission tomography (PET) scans. A needle will
guide a thin plastic tube (catheter) into an arm vein. A radioactive drug will be
injected into the plastic tube. This is a tracer that helps researchers understand the
PET images.
- Participants who have the dopamine scan will have to fast for 4-6 hours before the scan.
They will take a pill to help direct the tracer to the brain one hour before the scan.
- Each scan will last about 1.5 hours.
- Participants will be asked to drink a lot of fluids and empty their bladder frequently
for the rest of the day after each scan.
Phase:
Phase 1
Details
Lead Sponsor:
National Institutes of Health Clinical Center (CC)