The purpose of this study is to find objective biomarkers of vaso-occlusion (blood vessel
blockage) in people with SCD. Using information from earlier studies and work being done,
researchers have developed a strategy to image VOC, using positron emission tomography (PET).
The ability to see and measure VOC in SCD patients can help patient care, by showing when and
how a VOC is occurring or going to occur. Studying this method will also help in future drug
research, as it will allow researchers to deliver promising new medications that target
hyper-adhesion and sickling in people with SCD.