PET/CT Imaging of Malignant Brain Tumors With 124I-NM404
Status:
Completed
Trial end date:
2016-05-17
Target enrollment:
Participant gender:
Summary
The purpose of this study is to evaluate diagnostic imaging techniques using 124I-NM404
PET/CT in humans with brain metastases and GBMs. This goal will be accomplished by
determining the optimal PET/CT protocol and comparing PET tumor uptake to MRI and calculating
tumor dosimetry. A future aim of this study will be to compare non-invasive PET/CT and MRI
findings with pathological specimens, which is the gold standard but is invasive and
impractical in many cases, to determine the sensitivity and specificity of both techniques
for accurately detecting tumor infiltration. The data obtained from this study will be used
to develop larger diagnostic and therapeutic trials in brain tumors. The long-term goals of
this research are to improve the diagnosis and treatment of malignant brain tumors by using
radioiodinated NM404.