PEG Versus PEG+Bisacodyl Versus Sennosides for Colon Cleansing Before Colonoscopy
Status:
Completed
Trial end date:
2011-11-01
Target enrollment:
Participant gender:
Summary
Background:
Polyethylene glycol (PEG) solution has been proven to be effective for large bowel cleansing
prior to colonoscopy in children. However, the high volume of fluid and its taste sometimes
lead to inappropriate cleansing of the bowel, thus search for other bowel preparation is
needed.
Aim:
The efficacy and tolerability of three different bowel cleansing protocols used in children
for colonoscopy: high-volume PEG compared with low-volume PEG with stimulant laxative
(bisacodyl) compared with sennosides.
Methods:
Participants aged 10-18 years will be randomly assigned to receive either PEG 60 ml/kg/day or
PEG 30 ml/kg/day plus oral bisacodyl 10-15 mg/day or sennosides 2mg/kg/day for 2 days prior
to the colonoscopy. The outcome measures will be:bowel cleansing efficacy, scored by a
blinded endoscopist using the Ottawa scale and Aronchick Scale (the mean total score,
proportions of participants with excellent/good and with poor/inadequate bowel preparation),
and the patient satisfaction score(0-10)with the method of preparation for the colonoscopy
evaluated with the visual analog scale. Analysis will be done on an intention to treat basis.