PAracetamol Treatment in Hypertension: Effect on Blood Pressure (PATH-BP) Study

• Status: Completed
• Trial end date: 2019-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine if chronic paracetamol dosing increases blood pressure in patients with known high blood pressure.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Edinburgh
• Collaborators: British Heart Foundation; National Health Service, United Kingdom
• Treatments: Acetaminophen

Criteria

Inclusion Criteria:

• ≥18 years old, men or post-menopausal women (women with no periods for 12 months or more, or those who have had a surgical menopause)

• Treated hypertensive patients with an average daytime ambulatory blood pressure measurement (ABPM) <150/95mmHg on stable doses of one or more antihypertensive medication (at least one of which should be; an ACE inhibitor, angiotensin receptor blocker or diuretic) for 3 months, or untreated hypertensive patients with an average daytime ABPM ≥135/85 but <150/95.

Exclusion Criteria:

• History of ischaemic heart disease, cardiac failure, cerebrovascular disease, liver impairment (ALT/AST>50IU/L) or stage 3-5 chronic kidney disease.

• History of overdose or suicidal ideation

• Patients weighing <55kgs.

• Patients with chronic pain requiring treatment, with a known allergy to paracetamol, or concomitant use of non-steroidal anti-inflammatories , oral anticoagulants or corticosteroids.