Oxytocin Pharmacokinetics After Intramuscular Injection
Status:
Withdrawn
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
In this study people with knee arthritis so severe that a joint replacement is needed are
recruited for a one day study. Study participants will have an intravenous catheter (IV)
inserted in the forearm. A single intramuscular (IM) injection of oxytocin (Pitocin®), 17
micrograms will be administered and blood samples will be taken several times over the next
120 minutes. The amount of oxytocin will be measured in the blood samples.
The main purpose of this study is to sample the blood, before and after the administration of
oxytocin and calculate the pharmacokinetics (amount of oxytocin in the blood over time) of
oxytocin.