Oxytocin Effects on Cardiac Electrophysiology

• Status: Completed
• Trial end date: 2016-05-01
• Target enrollment: 0
• Participant gender: All

Summary

In this pilot study the investigators will perform a double-blind randomized trial of intranasal oxytocin on measures of cardiac refractoriness, among individuals who are undergoing clinically indicated catheter ablation procedures for paroxysmal atrial fibrillation. The investigators seek to enroll 20 patients for this study, for the purpose of estimating effect sizes for a larger future study.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: William Whang
• Treatments: Oxytocin

Criteria

Inclusion Criteria:

• Males and females older than 18 and younger than 85 years of age

• Undergoing catheter ablation for paroxysmal atrial fibrillation

• Presenting in sinus rhythm at the time of their procedure

Exclusion Criteria:

• Left ventricular ejection fraction <0.40

• Paced rhythm >50 percent of the time by device interrogation if a pacemaker is present