Oxycodone and Pregabalin for the Treatment of Oncological Neuropathic Pain

• Status: Completed
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is to assess tolerability and activity of oxycodone and pregabalin in combination for the treatment of oncological neuropathic pain with two different strategies.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Associazione Progetto Oncologia UMAN.A
• Collaborator: Mario Negri Institute for Pharmacological Research
• Treatments: Oxycodone; Pregabalin

Criteria

Inclusion Criteria:

• instrumental and clinical diagnosis of every malignant neoplasm

• presence of pain with a neuropathic component in the opinion of the physician

• presence of pain >=4(NRS)

• PS ECOG <3

• written informed consent

Exclusion Criteria:

• serum creatinine >2mg/ml or creatinine clearance <40 ml/min

• mild or severe hepatic insufficiency

• iatrogenic neuropathy caused by chemotherapeutic agents

• previous allergic reactions to oxycodone and pregabalin

• pregnancy or breastfeeding