Oxybutynin for Post-surgical Bladder Pain and Urgency

• Status: Recruiting
• Trial end date: 2025-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Bladder pain and urgency are common after bladder surgery. The objective is to determine if transdermal administration is superior to oral administration in alleviating pain and urgency.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of California, Davis
• Treatments: Mandelic Acids; Oxybutynin

Criteria

Inclusion Criteria:

• Patients who will undergo bladder surgery that requires an indwelling bladder catheter after surgery.

• Age Range: Four to 8 years of age are eligible for the study.

Exclusion Criteria:

• Patients who have had prior bladder surgery.

• Patients who have neurologic disease that could impair bladder sensation.

• Patients who are already taking antimuscarinic or antispasmodic medications.

• Patients with glaucoma, any neurologic disease, dementia, impaired mentation or disorder of the central nervous system.

• Patients taking any medication that affects the central nervous system such as antidepressant, anxiolytic or antipsychotic medications.

• Less than four years of age cannot have the transdermal patch due to fixed dose. Over 8 years of age: less than 5% of our patients, who undergo this surgery, are over 8 years of age and is usually a rare adolescent. Data in an older cohort may confuse the results since they respond differently to bladder surgery due to larger incision and longer hospital stay with a catheter.