Oxidative Stress in Robot-assisted Laparoscopic Radical Prostatectomy
Status:
Unknown status
Trial end date:
2011-04-01
Target enrollment:
Participant gender:
Summary
Gut hypoperfusion - reperfusion injury is an unavoidable event at the end of laparoscopic
surgery. It produces oxidative stress (reactive oxygen species). Malondialdehyde have been
demonstrated to be a reliable biomarker for the evaluation of oxidative stress in vivo.
Propofol (2, 6 - diisopropylphenol), a highly liposoluble anaesthetic, has a potent
antioxidant activity against lipid peroxidation in both in vitron and in vivo studies. On the
basis of this knowledge, the investigators hypothesized that propofol has preventive effect
for gut hypoperfusion - reperfusion induced injury in robot-assisted laparoscopic radical
prostatectomy.