Oxidative Stress and Vitamin E Requirements

• Status: Completed
• Trial end date: 2005-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if oxidative stress derived from cigarette smoking increases vitamin E requirements. The study will also assess the role of vitamin C in modulating vitamin E requirements. Vitamin E requirements will be assessed by measuring vitamin E in plasma as well as by measuring the excreted vitamin E metabolite in the urine.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Treatments: alpha-Tocopherol; Ascorbic Acid; Tocopherols; Tocotrienols; Vitamin E; Vitamins

Criteria

Inclusion criteria:

• non-smoking status or smokers (more than 1 pack per day)

• age: 18-35 y

• stable body weight, ranging between 80% and 130%,

• maintenance of normal exercise and activity patterns

• total cholesterol ≤ 7.758 mmol/L (300 mg/dl)

• triglyceride concentration ≤ 3.387 mmol/L (300 mg/dl)

Subjects will be excluded if they fulfill any one of the following:

• antioxidant supplement users

• resting blood pressure above 160/105 mm Hg

• engaged in aerobic activity more than five hours per week

• vegetarian or other restrictive dietary requirements

• fasting blood glucose concentration of ≥ 7.77 mmol/L (140 mg/dl)

• history of diabetes or uremia

• other known metabolic disease or medication use known to affect lipid metabolism