Oxidative Stress and Apoptosis of Energy Metabolism by Deferiprone From the Circulating Lymphocytes
Status:
Completed
Trial end date:
2020-03-01
Target enrollment:
Participant gender:
Summary
Peripheral blood mononuclear cells (PBMC) and platelets could be interesting ex vivo models
to study brain diseases. Indeed, there is no access to neurons from patients. However, PBMC
can exhibit different physiopathological mechanisms that are ubiquitous (i.e. oxidative
stress, mitochondriopathy with energy metabolism, inflammation, protein folding, iron
metabolism and programmed cell death ...). The platelets are pivotal in the healing system
with large range of growth factors. A new therapeutic concept of conservative iron chelation
with deferiprone for neuroprotection is under development.
The action of deferiprone on the different mechanisms and notably the oxidative stress are to
obtain from a collection of PBMC and platelets from patient having Parkinson's disease and
Amyotrophic lateral sclerosis and healthy controls to study ex vivo.
PBMC and platelets will be stored for future analyses.