Oxidant Status and Effect of Antioxidant in Immune Thrombocytopenia

• Status: Unknown status
• Trial end date: 2013-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Oxidative stress occurs as a result of increased activity of free radical-producing enzymes, decreased activity of free radical-removing enzymes, and insufficient levels of antioxidants. The most sensitive molecules to oxidation are lipids. Loss of cell membrane elasticity, increased cell fragility, and a shortened cellular life span results from oxidation of cell membrane lipids.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Antioxidants; Dexamethasone; gamma-Globulins; Immunoglobulins; Immunoglobulins, Intravenous; Methylprednisolone Hemisuccinate; Prednisolone; Rho(D) Immune Globulin

Criteria

Inclusion Criteria:

• 1. All patients less than 18 years with primary ITP; at initial presentation with platelet count less than 40 x 109/L attended Ain Shams Hematology clinic Children hospital from January 2013 and followed-up for 6 months.

2. For acute ITP, patients will be newly diagnosed (about one month within the diagnosis).

3. For chronic (12-24 months) and persistent (3-12 months) ITP patients.

Exclusion Criteria:

1. Patients' platelet count more than 40 x 109/L.; or above 18 years

2. Patients with secondary cause for thrombocytopenia.

3. Patients with any there associated chronic illness affecting oxidant status