Oxaliplatin, Gefitinib, and Radiation Therapy in Treating Patients With Locally Advanced or Metastatic Esophageal Cancer
Status:
Terminated
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, work in different ways to stop
tumor cells from dividing so they stop growing or die. Gefitinib may stop the growth of tumor
cells by blocking the enzymes necessary for their growth. Radiation therapy uses high-energy
x-rays to damage tumor cells. Combining oxaliplatin and gefitinib with radiation therapy may
kill more tumor cells.
PURPOSE: This phase I/II trial is studying the side effects and best dose of oxaliplatin when
given together with gefitinib and radiation therapy and to see how well they work in treating
patients with locally advanced or metastatic esophageal cancer.