OxSYPan: Oxford Study With Young People on Antidepressants

• Status: Completed
• Trial end date: 2015-11-10
• Target enrollment: 0
• Participant gender: All

Summary

Fluoxetine is commonly used to treat adolescent depression, but the neural mechanisms underlying antidepressant drugs in the young brain are still poorly understood. This study proposes to investigate the effects of a single dose of fluoxetine on emotional neural processing in a sample of depressed adolescents, using functional Magnetic Resonance Imaging (fMRI).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Oxford
• Treatments: Antidepressive Agents; Fluoxetine

Criteria

Inclusion Criteria:

• Current episode of depression with or without comorbid anxiety and in need of antidepressant medication (as assessed by the Adolescent Psychiatrist);

• Participant and parent/legal guardian (for participants younger than 16) are willing and able to give informed consent for participation in the study;

• Male or female, aged 13-18;

• Sufficiently fluent in English to understand the task and instructions.

Exclusion Criteria:

• Current or past psychosis or mania;

• Current substance misuse;

• Psychotropic medication usage within the past 6 weeks;

• Contraindication to fMRI (e.g. metal in body, claustrophobia, pregnancy, etc);

• Risk of waiting 5-7 days before the initiation of medication assessed as posing serious risk (as assessed by the Adolescent Psychiatrist).