Ovulation Induction in Clomiphene Citrate Resistant PCO Women
Status:
Completed
Trial end date:
2015-07-01
Target enrollment:
Participant gender:
Summary
Polycystic ovary syndrome (PCOS) affects 5-10% of women in childbearing age. Hyperinsulinemia
contributes to chronic anovulation commonly encountered in women with PCOS. The first choice
therapy is clomiphene citrate (CC). In CC resistant cases, the American College of Obstetrics
and Gynecology (ACOG) recommends the use of insulin sensitizer metformin. Other insulin
sensitizing agents include rosiglitazone and pioglitazone. Pioglitazone is said to improve
fertility and ovulation in patients with PCOS.CC may be associated with poor endometrial
thickening due to its antiestrogenic effect. Letrozole may improve this condition. In this
study we will compare the effect of combined letrozole-metformin with that of combined
letrozole-pioglitazone in ovulation induction in CC-resistant PCOS women