Outpatient Recovery From Acute Kidney Injury Requiring Dialysis

• Status: Recruiting
• Trial end date: 2022-10-29
• Target enrollment: 0
• Participant gender: All

Summary

There are currently no therapies to improve the chances of recovering enough kidney function to come off of dialysis after severe acute kidney injury. It is not known if current routine outpatient dialysis treatments are optimized to maximize the chances of recovery. The purpose of this pilot study is to see if we can feasibly and safely provide several changes to the way that dialysis is provided in outpatient dialysis centers which may improve the chances of recovery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of California, San Francisco
• Treatments: Furosemide

Criteria

Inclusion Criteria:

• AKI-D (acute kidney injury requiring dialysis), attributed at least in part to acute tubular necrosis by clinical nephrology team

• Age ≥ 18 years

• Pre-hospitalization eGFR ≥ 15 mL/min/1.73m2

• Being discharged to a participating outpatient dialysis unit (within 30 miles of UCSF)

Exclusion Criteria:

• Known loop diuretic allergy/intolerance

• Dialysis duration > 3 months

• Pregnant

• Prisoner

• Unable to consent

• Clinical team declines to allow approach for study