Overview

Outcomes Of Perioperative Pregabalin On Total Knee Arthroplasty

Status:
Completed
Trial end date:
2017-05-01
Target enrollment:
0
Participant gender:
All
Summary
This study aims to provide high quality evidence from a double-blinded, randomized controlled trial on the efficacy of perioperative pregabalin in reducing morphine requirements, improving pain scores and reducing chronic neuropathic pain when compared with placebo for primary total knee arthroplasty. It hence aims to improve on choice of analgesia adjuncts for total knee arthroplasty.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
National University Hospital, Singapore
Treatments:
Acetaminophen
Etoricoxib
Morphine
Pregabalin
Ropivacaine
Criteria
Inclusion Criteria:

- patients undergoing primary total knee arthroplasty

Exclusion Criteria:

- revision or bilateral arthroplasty, significant renal or hepatic impairment,
documented allergy or intolerance to NSAIDs, paracetamol, morphine or pregabalin,
chronic pain syndrome treated with chronic opioids, obstructive sleep apnea not
treated with continuous positive airway pressure, seizures, breastfeeding, inability
to use patient-controlled analgesia.