Osteoarthritis in Older Adults: Recovery of Mobility and Pain With a Topical Analgesic

• Status: Withdrawn
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Biofreeze® is a topical ointment that has menthol and alcamphor. Its analgesic effect lies in the stimulation of A and C fibers by cold and nociceptive stimulation, respectively, which is produced by menthol, apparently through the newly discovered receptor TRPM8 (Transient Receptor Potential melastatin-8) The aim of this study is to investigate if BIOFREEZE ® treatment (Performance Health Inc., Export, PA) improves symptoms associated with moderate knee osteoarthritis, which would decrease the immobility and isolation in older adults.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Chile
• Treatments: Analgesics; Menthol

Criteria

Inclusion Criteria:

• Moderate osteoarthritis of the knee

• Age 60 to 80 years

• Ambulatory

Exclusion Criteria:

• Other conditions that affect mobility

• Severe chronic diseases such as cardiac or renal failure

• Cancer

• Presence of gout

• Cognitive impairment