Organoid-Guided Chemotherapy for Stage IV Colorectal Cancer

• Status: Not yet recruiting
• Trial end date: 2025-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate whether chemotherapy guided by patient-derived tumor organoid drug test can improve the outcomes of stage IV colorectal cancer.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nanfang Hospital of Southern Medical University
• Collaborators: Sixth Affiliated Hospital, Sun Yat-sen University; Sun Yat-sen University
• Treatments: Fluorouracil; Irinotecan; Leucovorin; Oxaliplatin

Criteria

Inclusion Criteria:

• Age between 18 and 70

• Histological confirmed colorectal cancer

• Stage IV

• American Society of Anesthesiologists (ASA) score I~III

• No contraindication for chemotherapy

• No evidence of other malignant tumor

Exclusion Criteria:

• Refusing chemotherapy

• Pregnant or breast-feeding women

• Severe organ damage after chemotherapy, surgery or unable to continue to systemic chemotherapy