Organic Cation Transporter 1 (OCT1), on Response to Metformin in Healthy Subjects

• Status: Completed
• Trial end date: 2008-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Specific Objectives:

• To determine if individuals who carry a decreased or non-functional variant of OCT1 exhibit differences in the pharmacokinetics of metformin in comparison to individuals who carry the common allele.

• To determine if individuals who carry the decreased or non-functional variants exhibit differences in the response to metformin in comparison to individuals who carry the common allele.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of California, San Francisco
• Treatments: Metformin

Criteria

Inclusion Criteria:

• Previous participation in the Study Of Pharmacogenetics In Ethnically Diverse Populations (SOPHIE) study.

• Between the ages of 18 and 40.

• Possess a specific OCT1 genotype.

Exclusion Criteria:

• Taking any medications other than vitamins

• Individuals with anemia (hemoglobin < 12 g/dL), an elevation in liver enzymes to higher than double the respective normal value, or elevated creatinine concentrations (males ≥ 1.5 mg/dL, females ≥ 1.4 mg/dL)

• Pregnant at time of study.