Oral vs Intravesical Analgesia for Office Bladder Botox Injections

• Status: Recruiting
• Trial end date: 2021-03-01
• Target enrollment: 0
• Participant gender: Female

Summary

OnabotulinumtoxinA (Botox®) bladder injections are a highly effective treatment for overactive bladder and urgency urinary incontinence. The procedure is typically performed in the office setting with one of two medications to control comfort. However, the effectiveness of these medications has never been compared. The goal of this study is to determine which medication is better at providing comfort during bladder Botox® injections.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Women and Infants Hospital of Rhode Island
• Treatments: Lidocaine

Criteria

Inclusion Criteria:

• Non-pregnant, adult females 18 years of age or older

• Diagnosis of idiopathic overactive bladder

• Planning office-based bladder injection of onabotulinumtoxinA

• Willing and able to complete all study related items and interviews

• Grossly neurologically normal on exam

Exclusion Criteria:

• Known neurologic diseases (multiple sclerosis, Parkinson Disease, CVA within 6 months, myasthenia gravis, Charcot-Marie-Tooth disease, peripheral neuropathy, and complete spinal cord injury) believed to affect urinary function

• Planned injection of >100 units of onabotulinumtoxinA

• OnabotulinumtoxinA given for another indication within the previous 3 months (if cumulative dose would total >400 units)

• Any intradetrusor onabotulinumtoxinA injections in the previous 12 months

• Serum creatinine level greater than twice the upper limit of normal within the year prior to enrollment

• Allergy to lidocaine

• Allergy to onabotulinumtoxinA

• Allergy to phenazopyridine

• Untreated urinary tract infection (UTI)

• Currently pregnant or lactating.

• Known urinary retention (post-void residual >200mL) and inability to perform intermittent self-catheterization

• Uninvestigated hematuria (gross or microscopic)

• Current or prior bladder malignancy

• Previous bladder augmentation or surgically altered detrusor muscle

• Prior pelvic radiation

• Primary language other than English or Spanish