Oral vs IV Acetaminophen for Long-bone Fracture in Children
Status:
Recruiting
Trial end date:
2024-03-01
Target enrollment:
Participant gender:
Summary
Intravenous (IV) acetaminophen entered the Canadian market recently and children with acute
pain following a trauma are ideal candidates for the IV formulation as it may improve
analgesia and consequently decrease the amount of opioids needed to achieve pain control. Due
to the limited data on bioavailability, adverse effect profile and efficacy of IV versus oral
acetaminophen, it is of paramount importance to generate evidence-based data to guide
clinicians with a rational choice of route of administration of acetaminophen.
Therefore, we propose a pilot study to inform a future large randomized controlled trial
(RCT) to compare pharmacokinetics, feasibility, preliminary effects and side effects profile
of oral versus IV acetaminophen in children admitted for surgical fixation of a long-bone
fracture.