Oral Vitamin B12 as Potential Treatment of Recurrent Aphthous Stomatitis
Status:
Completed
Trial end date:
2008-01-01
Target enrollment:
Participant gender:
Summary
Background:
Recurrent aphthous stomatitis is a common phenomenon in Primary Medicine.Frequency of the
phenomenon can be as high as 25% of the general population and the recurrence of the problem
can be up to 50%.Different approaches for treatment are described: treatment with various
natural vitamins , local ointments , disinfectant agents for local treatment , local
antibiotic ointments , NSAID, local cortisone-steroids , and even medication on the basis of
immune-depressants of the immune system and systematic steroids .
Methods:
A double-blind study of daily administration of sublingual Vitamin B12 tablets manufactured
by Solgar (each tablet containing 1000 mcg. of Vitamin B12) opposed to placebo tablets.
Purpose of the research:
To investigate the effect of Vitamin B12 on the frequency of recurrent canker sores of the
mouth (RAS).
Study hypothesis:
Treatment with vitamin B12 will reduce the recurrence rate and will diminish the
symptomatology of RAS episodes.
Phase:
N/A
Details
Lead Sponsor:
Soroka University Medical Center
Treatments:
Hydroxocobalamin Vitamin B 12 Vitamin B Complex Vitamins