Oral Vitamin B12 Administration for Vitamin B12 Deficiency After Total Gastrectomy
Status:
Completed
Trial end date:
2008-11-01
Target enrollment:
Participant gender:
Summary
Pernicious anemia develops in 50% of total gastrectomized due to gastric cancer patients.
Lack of intrinsic factor, which is secreted by parietal cell from stomach wall causes
deficiency of cobalamin, which, in final, causes pernicious anemia. Thus, patients who had
undergone total gastrectomy needs to be provided externally with cobalamin. Until now,
intramuscular injection of cyanocobalamin has been the choice of treatment for cobalamin
deficiency, but it has demerits in that it causes discomfort of coming to the hospital to get
an injection, and in its high costs.
However, in pernicious anemia in old age and absorption disorder patients, it has been
reported that oral administration of cobalamin had effect of elevating serum vitamin B12.
Thus, this study was designed to prove the effect of oral administration of vitamin B12 in
total gastrectomized patients with cobalamin deficiency.
Phase:
Phase 2
Details
Lead Sponsor:
Yonsei University
Treatments:
Hydroxocobalamin Vitamin B 12 Vitamin B Complex Vitamins