Oral Versus Intravenous Antibiotics for the Treatment of Pleural Space Infection: a Randomized Controlled Pilot Trial

• Status: Not yet recruiting
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: All

Summary

We aim to conduct a pilot trial assessing oral versus intravenous therapy for pleural space infections.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: St. Joseph's Healthcare Hamilton
• Collaborator: Vaibhav Mokashi
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular

Criteria

Inclusion Criteria:

• Must meet our study definition of pleural space infection

• Age > or = 18 years old

• Life expectancy > 1 year

• Received intravenous or oral antibiotics for = or < 7 d from surgical intervention or received a total of = or < 7 d of antibiotics if no intervention performed

Exclusion Criteria:

• S. aureus bacteremia or endocarditis in the last 1 month

• Another concomitant infection requiring prolonged IV antibiotics

• Esophageal rupture or malignant pleural effusion

• Septic shock or systemic features requiring IV antibiotics

• Mycobacterial, fungal or parasitic pleural space infection

• No oral antibiotic options available

• Unlikely to comply with therapy