Oral Selenium Therapy for the Prevention of Mucositis
Status:
Unknown status
Trial end date:
2012-12-01
Target enrollment:
Participant gender:
Summary
Selenium as an antioxidant and anti-inflammatory agent could be effective in prevention of
mucositis induced by chemotherapy and radiotherapy. Other agents such as vitamin E, Zinc
sulfate, amifostine, beta carotene and benzidamine are indicated for prevention of mucositis
and positive effects are seen. Our purpose in this double blinded randomized study is to
evaluate the selenium effect on mucositis prevention in patient with acute myeloid leukemia
(AML) & acute lymphoblastic leukemia (ALL) whose received Busulfan and/or Cyclophosphamide
before Hematopoietic stem cell transplantation (HSCT).