Overview

Oral Selenium Therapy for the Prevention of Mucositis

Status:
Unknown status

Trial end date:
2012-12-01

Target enrollment:
0

Participant gender:
All

Summary

Selenium as an antioxidant and anti-inflammatory agent could be effective in prevention of mucositis induced by chemotherapy and radiotherapy. Other agents such as vitamin E, Zinc sulfate, amifostine, beta carotene and benzidamine are indicated for prevention of mucositis and positive effects are seen. Our purpose in this double blinded randomized study is to evaluate the selenium effect on mucositis prevention in patient with acute myeloid leukemia (AML) & acute lymphoblastic leukemia (ALL) whose received Busulfan and/or Cyclophosphamide before Hematopoietic stem cell transplantation (HSCT).

Phase:

Phase 1/Phase 2

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Tehran University of Medical Sciences

Treatments:

Selenium

Criteria

Inclusion Criteria:

- Patients with AML or ALL undergoing high dose chemotherapy with stem cell
transplantation

- Adequate renal and hepatic function

Exclusion Criteria:

- Taking selenium supplement before admission